Joan Mecsas Selected Research

Infections

2/2024	Critical role of growth medium for detecting drug interactions in Gram-negative bacteria that model in vivo responses.
1/2020	A Structure-Function-Inhibition Analysis of the Pseudomonas aeruginosa Type III Secretion Needle Protein PscF.
1/2020	Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection.
1/2019	Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions.
1/2019	Amino Acid Biosynthetic Pathways Are Required for Klebsiella pneumoniae Growth in Immunocompromised Lungs and Are Druggable Targets during Infection.
4/2018	A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage.
10/2016	Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.
9/2016	Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection.
2/2016	Bacterial Secretion Systems: An Overview.
1/2016	Klebsiella pneumoniae: Going on the Offense with a Strong Defense.

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Joan Mecsas Research Topics

Disease

25	Infections 02/2024 - 03/2006
4	Bacterial Infections (Bacterial Infection) 02/2024 - 12/2015
4	Plague (Bubonic Plague) 01/2019 - 02/2004
2	Pneumonia (Pneumonitis) 01/2020 - 11/2010
2	Yersinia Infections 01/2019 - 09/2016
2	Inflammation (Inflammations) 01/2017 - 06/2006
1	Hypersensitivity (Allergy) 03/2024
1	Candidiasis (Moniliasis) 08/2021
1	Ventilator-Associated Pneumonia 01/2020
1	Gastroenteritis 01/2019
1	Diarrhea 04/2018
1	Cross Infection (Nosocomial Infection) 04/2018
1	Pseudomonas Infections 10/2016
1	Weight Gain 01/2015
1	Colitis 06/2006
1	Coinfection 03/2006

Drug/Important Bio-Agent (IBA)

8	Virulence Factors (Pathogenicity Factors)IBA 01/2020 - 03/2006
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2007
5	Anti-Bacterial Agents (Antibiotics)IBA 02/2024 - 01/2016
4	Type III Secretion SystemsIBA 01/2020 - 08/2010
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2020 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 09/2016
2	Interleukin-17 (Interleukin 17)IBA 10/2016 - 01/2016
2	LipopolysaccharidesIBA 01/2016 - 01/2015
2	CytokinesIBA 12/2015 - 01/2013
2	VaccinesIBA 11/2010 - 02/2007
1	LipidsIBA 03/2024
1	Drug CombinationsIBA 02/2024
1	IntegrinsIBA 08/2021
1	Amino Acids FDA Link 01/2019
1	3-Phosphoshikimate 1-Carboxyvinyltransferase (3 Phosphoshikimate 1 Carboxyvinyltransferase)IBA 01/2019
1	Glyphosate (Roundup)IBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2017
1	Protein Translocation SystemsIBA 02/2016
1	Capsules (Microcapsules)IBA 01/2016
1	SiderophoresIBA 01/2016
1	InterferonsIBA 12/2015
1	Toll-Like Receptor 4IBA 12/2015
1	Alkaline PhosphataseIBA 01/2015
1	Complement System Proteins (Complement)IBA 01/2013
1	Transcription Factors (Transcription Factor)IBA 11/2010
1	Leucine-Rich Repeat ProteinsIBA 06/2010
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2009
1	Indicators and Reagents (Reagents)IBA 02/2007
1	AntigensIBA 02/2007
1	LactoferrinIBA 06/2006
1	Interferon-gamma (Interferon, gamma)IBA 03/2006
1	Chemokine ReceptorsIBA 02/2004

Therapy/Procedure

6	Therapeutics 02/2024 - 06/2006